Here are several synonyms for "antagonise," categorized by the specific nuance they convey:
To provoke or irritate:
- Irritate: To annoy or make someone frustrated.
- Provoke: To incite anger, resentment, or strong reaction.
- Annoy: To bother or disturb someone.
- Exasperate: To intensely irritate or frustrate.
- Vex: To annoy or worry someone.
- Pique: To irritate or provoke, often in a minor way.
- Rile: To make someone angry or annoyed.
- Nettle: To irritate or annoy someone slightly.
- Agitate: To make someone feel anxious or troubled.
- Harass: To persistently disturb or trouble someone.
- Badger: To repeatedly ask or bother someone.
- Needle: To tease or provoke someone playfully or maliciously.
To oppose or act against:
- Oppose: To act against or resist someone or something.
- Counteract: To act against something in order to reduce its force or neutralize it.
- Resist: To withstand the action or effect of something.
- Confront: To face someone in hostility or defiance.
- Contradict: To assert the opposite of what someone has said.
- Alienate: To make someone feel isolated or estranged.
- Estrange: To cause someone to be no longer friendly or affectionate.
To create hostility or animosity:
- Offend: To cause someone to feel hurt, upset, or resentful.
- Displease: To fail to satisfy or appeal to someone.
- Ruffle feathers: To annoy or upset someone.
- Make enemies: To cause someone to become hostile towards you.
- Set against: To cause someone to be hostile or opposed to another.
More formal synonyms:
- Incur the hostility of: To cause someone to become hostile towards you.
- Incense: To make someone extremely angry.
The best synonym to use will depend on the specific context and the degree and nature of the antagonism.

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